According to Hemrnasen (1973), a healthy adult weighing 70 kg breathes about 20,000 times a day on average, and consumes about 0.75 kg of oxygen a day.
The 2019 Nobel Prize in Physiology or Medicine revealed that cells can sensitively sense the oxygen content of their environment.
Under hypoxic conditions, the number of molecules called hypoxia-inducible factor (HIF) increases, causing changes in the expression of more than 300 genes, prompting cells to have a completely different metabolic pattern from that in oxygen-rich conditions.
Long-term hypoxia will lead to accelerated aging of the body and increased risk of disease.
With age, the oxygen uptake capacity of men decreases by nearly 2% each year, and the oxygen uptake capacity of women decreases by nearly 2.5% each year, so tissue hypoxia is common, and tissue hypoxia is more likely to cause the following common diseases: cardiovascular disease, lung disease, chronic infection, hypoxia in solid tumor lesions, obesity, snoring… To solve the above situation, hyperbaric oxygen chambers came into being.
With the growth of age, the body generally exists hypoxia, which affects the respiratory system, circulatory system, central nervous system, skin and other, hypoxia is also one of the causes of many diseases.
Oxygen is transported through the body in two ways: bound oxygen and dissolved oxygen. Bound oxygen: Most of the oxygen entering the blood combines with hemoglobin to form “oxygenated hemoglobin”, this part of oxygen is called bound oxygen, which is the main mode of oxygen transport. Hemoglobin in red blood cells is bound to milk gas, and its carrying capacity can be expressed by blood oxygen saturation, arterial blood oxygen saturation is 95~98%, venous blood 75%; Because hemoglobin content is relatively stable, oxygen saturation is relatively stable in healthy people.
Dissolved oxygen: Oxygen entering the blood, and a small part of oxygen in the form of a physical state, directly dissolved in the blood, this part of oxygen is called dissolved oxygen, which is clinically important. The amount of oxygen dissolved in the plasma is much less than the bound oxygen, and the dissolved oxygen is proportional to the pressure. In some areas, the capillaries are so narrow that blood cells can’t cross them, and they have to rely on dissolved oxygen in the plasma.
In summary, by increasing the atmospheric pressure of the human environment and the oxygen concentration of the inhaled air, the oxygen supply of the whole body can be improved.
In some parts of the body, the capillaries are so narrow that blood cells cannot pass through them, bound oxygen cannot reach them, and they can only rely on dissolved oxygen. The oxygen generator has little change in the dissolved oxygen in the blood, which is also the reason why the ordinary oxygen absorption effect in the plateau area is general. Raising the dissolved oxygen in the blood by increasing the pressure is a more feasible approach.
The hyperbaric oxygen chamber can maintain the oxygen partial pressure within a safe and effective range by flexibly adjusting the oxygen concentration or pressure, and gently and effectively improve the oxygen delivery to tissues and organs by increasing dissolved oxygen.
Hypoxia can activate the HIF signaling pathway, leading to multiple changes: At the cellular level, HIF promotes multiple gene expression changes related to metabolism, cell survival or death, resulting in changes in cell survival mode, insufficient energy (ATP) supply, and increased production of harmful free radicals (ROS);
At the body level: long-term hypoxia leads to elevated levels of systemic chronic inflammation, accelerating inflammatory aging and the progression of chronic diseases; Chronic inflammation repeatedly stimulates the immune system, causing immune disorders; For cancer patients, long-term anoxic focal environment is more conducive to cancer cell survival, migration, and accelerate disease progression.
By periodically replenishing oxygen in tissues and organs, hyperbaric oxygen inhibits HIF signals, improves cell metabolism, and improves human health.
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